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Plate XIII.
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Oppenheim and Cassirer's Original 1907 Characterization of a Subcortically Spread Multifocal Encephalitis:

Fig. 4, "Inflammatory foci" in cerebral cortex and subcortical white matter at weak magnification; fig. 5, (hemorrhagic) white matter foci at stronger magnification. The "dot-shaped" or streaky multifocal damages' perivascular spread is obvious.

Lesion Character:
The illustrations of the dissemination of "encephalitic foci " according to a random involvement of minor blood vessels, and of their evolution through intensified effusions from transitional vessels make the differences between "(blood-borne) encephalitis" and cerebral multiple sclerosis particularly explicit.


Significance of the Documentation:
The text to the given illustration pointed out that a larger "encephalitic lesion's" origin in a confluence of small "inflammatory foci" may be evident from an increasingly dense clustering of perivascular infiltrates towards a corresponding larger lesion's edge. Large "encephalitic" lesions were thus indicated to develop in a principally different way from the cerebral plaques of multiple sclerosis.

© Dr. F. Alfons Schelling, M.D.